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Cardiovascular biology of the GIP receptor

It represents a strategic evolution in therapeutic development, moving beyond single-target approaches to multi-receptor agonism

As the confounding structure for the head-to-head comparison of tirzepatide versus semaglutide was expected to be more similar to the tirzepatide versus dulaglutide benchmarking study, we proceeded with the prespecified analysis plan that included death in the primary composite MACE outcome

Moreover, both endogenous GLP-1 and GLP-1RAs interact with circumventricular organs (CVOs), such as the area postrema and subfornical organ, which lack a fully intact BBB