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MONOTHERAPY Considering that pain relief of DPN is not sufficient in monotherapy because of the difficulty increasing the dose given the side effects of the drugs, combination or sequential therapy has been attempted

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However, more studies for evaluating the CBD pharmacokinetics, drug interactions, and potential side effects are needed in this regard

Route-specific and Other Contraindications: Bacteriostatic Water must not be used for large-volume intravenous fluid replacement or hydration therapy

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Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy