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Bariatric Surgery : Surgery carries significant risks and long-term nutritional deficiencies

Growth hormone-releasing peptides (GHRPs) like Ipamorelin work by binding to ghrelin receptors (GHS-R1a) on pituitary cells, providing an more stimulus for GH release through a pathway distinct from GHRH

These include hormones related to insulin secretion, such as incretins like GLP-1 and GIP

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Tirzepatide, a dual-agonist peptide, has shown significant results with a 22.5% weight loss over 72 weeks at a 15 mg dose (Jastreboff et al., NEJM), making it one of the most effective therapies for obesity