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This improves renal perfusion and helps balance filtration pressures within the kidney, counteracting the hyperfiltration that drives nephropathy

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Well-studied and safe in most individuals

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The method of embodiment 21, wherein the thiophene carboxamide is a compound of Formula (I), Formula (II), Formula (III), Formula (IV), Formula (V), Formula (VI), Formula (VII), Formula (VIII), Formula (IX), Formula (X) or Formula (XI)

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