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Greater retention of BA suggests that supplementation in a sustained-release format might lead to greater increases in muscle carnosine compared to an instant release (e.g., powder) formulation, although the authors did not measure muscle carnosine in this study

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Biol Psychiatry 88:369380 Miller AH, Maletic V, Raison CL (2009) Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression

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Epigenetic modifications as therapeutic targets

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In addition, Pycnogenol increased the total antioxidant status (TAS) and improved the glutathione levels, another index for antioxidant capacity in the children with ADHD ( administration, while reduced glutathione (GSH) was significantly increased by 26.8% after one month and by 36.4% after 2 months compared to baseline ( s effects on ADHD symptoms by improving the antioxidant status

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