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Abstract Alzheimer's disease (AD) is a progressive and deleterious neurodegenerative disease, strongly affecting the cognitive functions and memory of seniors worldwide
This is proposed to be mediated by TRX1 oxidation by hydrogen peroxide which causes dissociation of ASK1 thereby triggering anti-apoptotic factors via downstream activation of MAPK kinase MKK3/MKK6/p38 and MKK4/MKK7/JNK pathways (Wagner et al
Results Control of TNF--dependent gene expression changes by GSTM1 in cultured astrocytes To evaluate the role of GSTM1 in astrocyte activation during acute brain inflammation, we examined the role of GSTM1 in TNF--dependent transcriptional program in primary mouse astrocytes
doi: 10.1016/0300-483x(94)02983-2 32 MengX.EarnshawC
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