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Once-daily oral semaglutide is the only oral GLP-1 receptor agonist currently available, with the 14 mg dose associated with significant improvements in HbA1c and body weight versus liraglutide 1.8 mg (the highest dose of liraglutide approved for treating type 2 diabetes) after 52 weeks in the PIONEER 4 clinical trial, in people with inadequate glycemic control on metformin with or without a sodium-glucose cotransporter-2 (SGLT-2) inhibitor [11]