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If youve been following metabolic research, youve likely noticed two compounds generating significant scientific interest: tirzepatide and retatrutide

Retatrutide is now in Phase 3 trials (the TRIUMPH program) for obesity, obesity with Type 2 diabetes, sleep apnea, and knee osteoarthritis

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Most injectable formulationssuch as semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda)can be administered at any time, regardless of meals

doi: 10.1111/dom.16366

however, the ECDs in these structures had been truncated, and hence the conformation of the ECD in peptide-free or inactive states remain unknown